表面增强拉曼散射 (Surface-Enhanced Raman Scattering, SERS) 技术是基于分子振动指纹信息的分析方法，灵敏度高，选择好，可无损现场检测，加之水体系干扰小，在生物样本分析和医学早期诊断等领域有潜在的应用前景。纳米酶是人工模拟酶，与天然酶相比，易于批量制备、种类多样和环境稳定的优点。金属有机框架化合物 (Metal-organic framework, MOF) 便于设计和合成，具有介孔晶体结构，比表面积大，可固载其它纳米材料，提高稳定性。本综述关注纳米酶、MOF与SERS基底复合提高分析性能和稳定性，重点介绍了基于MOF/纳米酶/SERS技术平台在生物医药分析领域的应用现状与展望。

Surface-enhanced Raman Scattering (SERS) is an analytical method based on molecular vibration fingerprint information, which has high sensitivity, good selectivity, nondestructive and on-site detection, and is free from the interference of water system. It has potential application in the fields of biological analysis and early diagnosis. Compared with natural enzyme, nanoenzyme as an artificial mimic enzyme presents the advantages of easy and scalable preparation, diversity of enzymatic activity via rational design as well as long-term environmental stability. Metal-organic framework (MOF) with mesoporous crystal structure, large specific surface area could be easily synthesized, which is beneficial to immobilization of other nanomaterials to improve stability and realize the multifunctional performance. This short review concerns on nano-enzyme, MOF and SERS substrate assembly to advance the figure of analytical merit, and focuses on the current explorations of MOF/nanozyme/SERS platform in the field of biomedical analysis and prospects.