31 kinds of explosives and 73 kinds of drugs were recorded the Raman Spectrum, the correct region of Raman spectrum was selected to be the normal to used in database. Database of normal Raman spectrum and information search system is build by software. In correct information of Raman frequency shift and height is recorded in the database. The Raman spectrum of unknown was compared with region of Raman spectrum, Raman peaks that are strong, are curve fitted, then the with the normal Raman spectrum in the database by information search system, the result is correct. The database has the function of add, delete, back up, recover and subtract baseline. Some facts will influence the search result is analyzed.