Application of nano-biosensor in exosome isolation and detection

WANG Xiaojie, BAI Lu, FU Kexin, ZHANG Yuying, XIE Wei

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Chinese Journal of Light Scattering ›› 2019, Vol. 31 ›› Issue (4) : 291-305. DOI: 10.13883/j.issn1004-5929.201904001
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Application of nano-biosensor in exosome isolation and detection

  • WANG Xiaojie1, BAI Lu2, FU Kexin1, ZHANG Yuying1*, XIE Wei2
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Abstract

Exosomes are a class of small cell-derived vesicles that contain lipid, protein and nucleic acid, and participate in various physiological and pathological processes. After years of study, exosomes are increasingly being recognized as promising biomarkers of liquid biopsies for disease diagnosis and prognosis, and considered as a long-range carrier in intercellular communication. With the development of controllable synthesis and surface modification technologies, nanomaterials-based biosensors show unique advantages for detection of cells, proteins and nucleic acids. In this review, we focus on recent advances in nano-biosensor for exosome isolation and detection, and the challenges and prospects of future application of nano-biosensor in exosome research are discussed as well.

Key words

exosomes / nano-biosensor / isolation / detection / liquid biopsies

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WANG Xiaojie, BAI Lu, FU Kexin, ZHANG Yuying, XIE Wei. Application of nano-biosensor in exosome isolation and detection. Chinese Journal of Light Scattering. 2019, 31(4): 291-305 https://doi.org/10.13883/j.issn1004-5929.201904001

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