Interfacial Self-Assembled Large-Scale Monolayer Film with Ligand Exchanged Au Nanodumbbells for in situ SERS Drugs Detection

SHEN Wei, ZHOU Liang, DONG Ronglu, YU Daoyang, TANG Xianghu

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Chinese Journal of Light Scattering ›› 2019, Vol. 31 ›› Issue (4) : 353-360. DOI: 10.13883/j.issn1004-5929.201904007
Application in Chemistry and Biology Researches

Interfacial Self-Assembled Large-Scale Monolayer Film with Ligand Exchanged Au Nanodumbbells for in situ SERS Drugs Detection

  • SHEN Wei1, ZHOU Liang2, DONG Ronglu3, YU Daoyang1, TANG Xianghu1,3*
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Abstract

In this article, the strategy of liquid-liquid interfacial self-assembled large-scale monolayer film with ligand exchanged Au nanodumbbells for in situ drugs Detection by surface-enhanced Raman spectroscopy (SERS) was developed. The self-assembled AuNDs provides efficient hotspots to create great SERS enhancement, which provides high sensitivity and reproducibility as the SERS-active substrate. Besides, this strategy was exploited to detect drug molecules in human urine for cyclohexane-extracted targets acting as the oil phase to form an oil/water interface. The self-assembled nanofilm can be used for detect methamphetamine down to 0.1 ppm levels in human urine, which exhibits an excellent practicability and a great promise for rapid, credible, and on-spot drug detection.

Key words

Surface-enhanced Raman spectroscopy / Au nanodumbbells / Interfacial self-assembled / Methamphetamine / Human urine

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SHEN Wei, ZHOU Liang, DONG Ronglu, YU Daoyang, TANG Xianghu. Interfacial Self-Assembled Large-Scale Monolayer Film with Ligand Exchanged Au Nanodumbbells for in situ SERS Drugs Detection. Chinese Journal of Light Scattering. 2019, 31(4): 353-360 https://doi.org/10.13883/j.issn1004-5929.201904007

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