Study on Breast Cancer by Fourier Transform Infrared Spectroscopy Imaging

LU Yanfei, ZHU Yongkang, ZHAO Yuan, XU Xinyu, YIN Jianhua

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Chinese Journal of Light Scattering ›› 2020, Vol. 32 ›› Issue (1) : 78-83. DOI: 10.13883/j.issn1004-5929.202001010
Application in Chemistry and Biology Researches

Study on Breast Cancer by Fourier Transform Infrared Spectroscopy Imaging

  • LU Yanfei1, ZHU Yongkang1, ZHAO Yuan1, XU Xinyu2*, YIN Jianhua1*
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Abstract

Fourier transform infrared spectroscopy (FTIR) imaging technique can be used to simultaneously obtain spatial distribution and infrared spectral information of samples. In this study, when in vitro breast tissue samples were investigated by using FTIR imaging, and the differences between healthy and cancerous breast tissues were compared by characteristic band absorbance ratio (area ratio) images combining with FTIR spectroscopy analysis. It was found that, compared with healthy tissues, the characteristic band absorbance ratios in cancerous tissues significantly increased in the case of A1087/A1455、A1238/A1455、A1550/A1455、A1650/A1455, and reduced in the case of A1160/A1087、A1740/A1550. The results demonstrated that the change rule of bio-macromolecule contain in carcinogenesis of breast tissue, which reflected the accuracy, visualization and feasibility of FTIR imaging technique in the diagnosis of breast cancer. Therefore, FTIR imaging has potential to become an accurate and effective technical means for basic research and clinical diagnosis.

Key words

Fourier transform infrared spectroscopy imaging / Breast cancer / characteristic band / absorbance ratio

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LU Yanfei, ZHU Yongkang, ZHAO Yuan, XU Xinyu, YIN Jianhua. Study on Breast Cancer by Fourier Transform Infrared Spectroscopy Imaging. Chinese Journal of Light Scattering. 2020, 32(1): 78-83 https://doi.org/10.13883/j.issn1004-5929.202001010

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