Na_0.5K_0.5NbO₃ is a new type of lead-free piezoelectric material. Understanding the crystal structure change of the material under high pressure is conducive to improving the performance and stability of a series of potassium sodium niobate-based piezoelectric materials. However, there is still a lack of experimental research on the phase structure evolution of this material under high pressure. In this study, the high-pressure Raman spectroscopy technology based on diamond anvil cell (DAC) was used to study the high-pressure Raman spectroscopy characteristics and pressure-induced phase transition behavior of Na_0.5K_0.5NbO₃. It is found that the reversible phase transition process of orthogonal phase to tetragonal phase and tetragonal phase to cubic phase will occur in turn due to the change of vibration mode of NbO₆ octahedron under high pressure, and the pressures of phase transition are about 4.0 - 5.5 GPa and 5.5 - 6.4 GPa respectively.