Predictive
value of Raman spectroscopy in hypertensive disorder complicating pregnancy
Author information+
1.Department of
Cardiovascular Medicine, Xiangyang No.1 People's Hospital, Hubei University of
Medicine, Xiangyang 441000, Hubei Province, P.R.C；<span>2.Department of Peadiatrics, Xiangyang No.1 People's Hospital, Hubei
University of Medicine, Xiangyang 441000, Hubei Province, P.R.C
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Published
2023-03-15
Issue Date
2023-04-28
Abstract
To explore the value of Raman
spectroscopy in predicting hypertensive diseases during pregnancy. Methods:From September 2020 to December 2021,96 pregnant
women who met the requirements of this study in the Xiangyang No.1 People's Hospital, affiliated to Hubei University of Medical,were selected as
subjects,including 46 cases of pregnancy induced hypertension (experimental
group) and 50 normal pregnant women (control group).Fasting venous blood was
taken from two groups of pregnant women during 12-20 weeks of pregnancy, and their
serum was detected by Raman spectrum. Statistical analysis of the original map
data, the use of machine learning SVM algorithm for data identification
analysis, and finally do peak intensity analysis and attribution analysis .Results:There
are significant differences in the peak displacement of Raman waves between the
experimental group and the control group in 726cm-1, 749cm-1, 876cm-1, 899cm-1,
935cm-1, 951cm-1, 1302cm-1, 1446cm-1, 2879cm-1, and 1123cm-1-1127cm-1,
1152cm-1-1155cm-1, 1263cm-1-1270cm-1, 1655cm-1-1667cm-1, 2910cm-1-2965cm-1. In
the two-classification identification, the identification accuracy of the
experimental group and the control group was 92%, and its specificity and
sensitivity were 94.8% and 88.5%, respectively.Conclusion: According to
the Raman spectral data obtained in this experiment,we can make a good
distinction between the experimental group and the control group, which is
helpful to distinguish pregnancy-induced hypertension from healthy people.
Raman spectrum may be used as an auxiliary method for predictive diagnosis of
pregnancy-induced hypertension.
ZHAO Huiying, LI Wenjun, LIU Fuyuan.
Predictive
value of Raman spectroscopy in hypertensive disorder complicating pregnancy. Chinese Journal of Light Scattering. 2023, 35(1): 33-38 https://doi.org/10.13883/j.issn1004-5929.202301005
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