Fourier transform infrared spectroscopy combined with curve fitting technology was used to study the ginger medicinal materials stored for 5 years, in order to explore the composition changes of ginger medicinal materials stored for 5 years. The results showed that the original infrared spectra were similar, and the main substances reflected in the spectra were volatile oils, flavonoids, sugars, amino acids, etc. Local amplification and second derivative processing of original spectra of 1300 ~ 1450 cm-1 with large differences in spectra showed that 1384cm-1 and 1410cm-1 had significant differences in peak strength and peak position, and it was inferred that the content and internal structure of compounds containing isopropyl and tert-butyl had changed. Combined with absorbance ratio method and curve fitting area quantitative analysis, the content of volatile oil of 22 species of ginger showed a decreasing trend and the content of carbohydrate showed an increasing trend with the change of storage time. The results showed that Fourier transform infrared spectroscopy combined with curve fitting could provide an effective method for quality analysis of ginger.