10 kinds of pigment were tested by laser Raman spectroscopy, and we classify the obtained experimental data into six categories though Raman peaks. Through the experiment, it is found that the pigment producted by domestic and foreign are different, the same domestic manufacturers of different types of seal pigment vary from each other, different manufacturer’s pigment components have the same. Raman spectroscopy can effectively detect pigment material seals which contain big red or bronze red. The setting of various parameters has great influence on the experimental data. Using the method of control variables, we analysis the influence of the sample itself, the experimental environment, experimental conditions, parameter settings and other factors.